We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

African Folk Drug Modulates Critical Potassium Channel Protein

By LabMedica International staff writers
Posted on 29 Nov 2018
A leaf extract used for hundreds of years in African folk medicine was shown to act by influencing the behavior of a protein that forms a critical potassium channel found in many human organs.

While, a leaf extract from the shrub Mallotus oppositifolius, has been used as an herbal medicine across Africa for centuries to treat a variety of illnesses and disorders including diabetes, pain, headaches, paralysis, and epilepsy; the molecular mechanism for its action has not been well established.

Image: Two components of Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs. The image shows a computer model illustrating the novel herbal component, CPT1, an isovaleric acid molecule (green), occupying a novel binding site (R243, red) to activate KCNQ1 (Photo courtesy of Dr. Geoffrey Abbott, University of California, Irvine School of Medicine).
Image: Two components of Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs. The image shows a computer model illustrating the novel herbal component, CPT1, an isovaleric acid molecule (green), occupying a novel binding site (R243, red) to activate KCNQ1 (Photo courtesy of Dr. Geoffrey Abbott, University of California, Irvine School of Medicine).

The ubiquity and importance of the protein KCNQ1 (potassium voltage-gated channel subfamily Q member 1) make it a strong candidate for explaining the underlying mechanistic basis of the therapeutic effects of Mallotus. Therefore, investigators at the University of California, Irvine (USA) screened leaf extract components for KCNQ1 activity.

They reported in the November 14, 2018, online edition of the journal Science Advances that they had identified two components of the Mallotus leaf extract that bound to a previously unrecognized binding site on KCNQ1. The two components, mallotoxin (MTX) and 3-ethyl-2-hydroxy-2-cyclopenten-1-one (CPT1), activated KCNQ1 channels by an unexpected, novel mechanism - binding to a novel drug site at the foot of the voltage sensor. MTX and CPT1 activated KCNQ1 by hydrogen bonding to the foot of the voltage sensor, a previously unidentified drug site, which was also found to be essential for MTX activation of the related KCNQ2/3 channel.

"Genetic disruption of KCNQ1 causes lethal cardiac arrhythmias and is also associated with gastric cancer, type II diabetes, and thyroid and pituitary gland dysfunction. KCNQ2/3 disruption causes epilepsy and severe developmental delay. Therefore, new strategies are needed to therapeutically activate these potassium channels and overcome the effects of genetic disruption. The discovery of novel botanicals that might help in KCNQ drug development strategies highlights the importance of protecting plant species that can produce novel therapeutics. Factors including habitat loss, over-collecting, and climate change are threatening this invaluable resource," said senior author Dr. Geoffrey Abbott, professor of physiology and biophysics at the University of California, Irvine.

Related Links:
University of California Irvine


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay

Latest BioResearch News

Genome Analysis Predicts Likelihood of Neurodisability in Oxygen-Deprived Newborns

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

New Method Simplifies Preparation of Tumor Genomic DNA Libraries